It's about a year since I asked for others' experience with using fifth comma mean tone tuning in another thread. The answers I received were sufficiently encouraging for me to take the plunge and have my 48 key Crabb Crane duet tuned to this temperament. I haven't regretted it for a moment.
A brief explanation before I detail my experience. The almost ubiquitous equal temperament (ET) tuning has been understood for centuries, but was shunned in favour of other tuning temperaments un